Figure 5.

Effect of butyrate on liver glucose and lipid metabolism in vivo. Liver transcriptome was compared between HFD and HFD + 400 mg·kg⁻¹ NaBu groups. (a) Gene ontology term enrichments with Bonferroni correction for differentially expressed genes. (b) Heatmap of differentially expressed gene levels (log₂) involved in glucose and lipid metabolism as assessed by RNA‐sequencing analysis. (c) Pearson correlation analysis between differentially expressed genes and phenotypes of atherosclerosis in mice treated with HFD or HFD + 400 mg·kg⁻¹ NaBu. (d) Pearson correlation between aorta lesion area and Cyp7a1 levels in liver of mice treated with HFD or HFD + 400 mg·kg⁻¹ NaBu. (e) Representative Western blot analysis of the indicated hepatic protein levels that involved in RCT. (n = 7 for chow group, n = 8 for other groups)