Figure 6.

Intrathecal application of 16‐μg 3β‐OH during isoflurane anaesthesia alleviates mechanical but not thermal hyperalgesia after surgery in rats. (a) Time course showing baseline measurements to mechanical stimulus determined 2 days before the incision and mechanical nociception assessment post‐injection in incised rats. Intrathecal injections of either 3β‐OH or vehicle were performed 5 min before the incision. Mechanical hyperalgesia was assessed 2 hr, as well as on post‐operative days 1, 2, and 5 (POD 1, 2, and 5). (b) Time course of anti‐hyperalgesic effect of 3β‐OH on mechanical hyperalgesia after intrathecal injections (n = 6 per group, P < .05, two‐way RM ANOVA). (c) Time course of anti‐hyperalgesic effect of 3β‐OH on thermal hyperalgesia after intrathecal injections (n = 6 per group, P > .05, two‐way RM ANOVA). Each data point represents the mean ± SEM