Table 7.
Multivariable Linear Regression Models for Factors Associated With FSIQ, PIQ, and VIQ at 48 to 72 Months of Age After Surgical Palliation for Classic HLHS, Excluding Patients With Pre‐Fontan Disability and Chromosomal Abnormality (N=57): Linear Regression Coefficient (β) and 95% CI
| Variable | FSIQ | P Value | PIQ | P Value | VIQ | P Value |
|---|---|---|---|---|---|---|
| Coefficient (95% CI) | Coefficient (95% CI) | Coefficient (95% CI) | ||||
| Norwood | ||||||
| Age at Norwood, d | −0.71 (−1.50 to −0.06) | 0.069 | ||||
| Sepsis | −11.09 (−19.41, −2.30) | 0.014 | −11.23 (−19.44, −2.80) | 0.010 | −9.30 (−18.49 to −0.57) | 0.037 |
| BCPA | ||||||
| Lowest PaO2 (POD 2–5) | 0.55 (−0.03, 1.14) | 0.065 | 0.68 (0.13–1.23) | 0.016 | ||
| Fontan | ||||||
| Age at Fontan, y | −6.20 (−10.71, −2.00) | 0.005 | −6.50 (−10.89, −2.60) | <0.001 | −4.05 (−8.30 to −0.31) | 0.068 |
| Demographics | ||||||
| Race (European) | 8.70 (0.49–16.90) | 0.038 | ||||
| Socioeconomic statusa | 0.24 (0.02–0.46) | 0.032 | ||||
The adjusted R 2 values for each model were 0.29 for full‐scale intelligence quotient (FSIQ), 0.39 for performance intelligence quotient (PIQ), and 0.23 for verbal intelligence quotient (VIQ).
BCPA indicates bidirectional cavopulmonary anastomosis; HLHS, hypoplastic left heart syndrome; PaO2, arterial partial pressure of oxygen; POD, postoperative day.
a
Socioeconomic status as measured by the Blishen index.