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. 2020 Feb 11;9(4):e014676. doi: 10.1161/JAHA.119.014676

Table 1.

Baseline Characteristics

All patients (n=1101) OPR (n=905) HPR (n=196) P Value
Age, y 68.8±10.4 68.4±10.3 70.5±10.1 0.010
≥75 y 351 (32) 274 (30) 77 (39) 0.014
Male sex, (%) 940 (85) 780 (86) 160 (82) 0.102
Hypertension, (%) 695 (63) 564 (62) 131 (67) 0.235
Hypercholesterolemia, (%) 684 (62) 557 (61) 127 (65) 0.395
Diabetes mellitus, (%) 296 (27) 230 (25) 66 (34) 0.018
CKD, (%) 100 (9) 76 (12) 24 (17) 0.126
Previous MI, (%) 554 (50) 451 (50) 103 (53) 0.490
Previous PCI, (%) 492 (45) 413 (46) 79 (40) 0.174
Previous CABG, (%) 154 (14) 119 (13) 35 (18) 0.085
ACS, (%) 256 (23) 207 (23) 49 (25) 0.523
LVEF (%) 45.3±12.6 45.2±12.9 45.4±12.6 0.858
LVEF <0.40, (%) 372 (34) 305 (34) 67 (34) 0.905
Multivessel disease, (%) 936 (85) 762 (84) 174 (89) 0.104
Three‐vessel disease, (%) 585 (53) 479 (53) 106 (54) 0.769
CTO vessel
LAD, (%) 330 (30) 271 (30) 59 (30) 0.440
RCA, (%) 468 (42) 379 (42) 89 (45)
Second generation DES, (%) 508 (56) 417 (56) 91 (60) 0.358
Successful CTO PCI, (%) 889 (81) 738 (81) 151 (77) 0.147
Complete revascularization, (%) 772 (70) 651 (72) 121 (62) 0.005
Platelet Reactivity: ADP Test Results by LTA
Overall population
P2Y12 antagonist responders n=905
Mean, (%) 44±16
Median, (%) 51 [15–68]
HPR on clopidogrel therapy n=196
Mean, (%) 77±6
Median, (%) 77 [71–90]
HPR group on clopidogrel
“not switched” n=114
Mean, (%) 78±6
Median, (%) 76 [71–92]
“switched” n=82
Mean, (%) 46±17
Median, (%) 49 [19–74]

Values are mean±SD, number of patients (%) and median (%) [25th–75th percentiles]. ACS indicates acute coronary syndrome; ADP, adenosine diphosphate; CABG, coronary artery bypass grafting; CKD, chronic kidney disease; CTO, chronic total occlusion; DES, drug‐eluting stent; HPR, high platelet reactivity; LAD, left anterior descending artery; LTA, light transmission aggregometry; LVEF, left ventricular ejection fraction; MI, myocardial infarction; OPR, optimal platelet reactivity; PCI, percutaneous coronary intervention; RCA, right coronary artery.