Table 1.
All patients (n=1101) | OPR (n=905) | HPR (n=196) | P Value | |
---|---|---|---|---|
Age, y | 68.8±10.4 | 68.4±10.3 | 70.5±10.1 | 0.010 |
≥75 y | 351 (32) | 274 (30) | 77 (39) | 0.014 |
Male sex, (%) | 940 (85) | 780 (86) | 160 (82) | 0.102 |
Hypertension, (%) | 695 (63) | 564 (62) | 131 (67) | 0.235 |
Hypercholesterolemia, (%) | 684 (62) | 557 (61) | 127 (65) | 0.395 |
Diabetes mellitus, (%) | 296 (27) | 230 (25) | 66 (34) | 0.018 |
CKD, (%) | 100 (9) | 76 (12) | 24 (17) | 0.126 |
Previous MI, (%) | 554 (50) | 451 (50) | 103 (53) | 0.490 |
Previous PCI, (%) | 492 (45) | 413 (46) | 79 (40) | 0.174 |
Previous CABG, (%) | 154 (14) | 119 (13) | 35 (18) | 0.085 |
ACS, (%) | 256 (23) | 207 (23) | 49 (25) | 0.523 |
LVEF (%) | 45.3±12.6 | 45.2±12.9 | 45.4±12.6 | 0.858 |
LVEF <0.40, (%) | 372 (34) | 305 (34) | 67 (34) | 0.905 |
Multivessel disease, (%) | 936 (85) | 762 (84) | 174 (89) | 0.104 |
Three‐vessel disease, (%) | 585 (53) | 479 (53) | 106 (54) | 0.769 |
CTO vessel | ||||
LAD, (%) | 330 (30) | 271 (30) | 59 (30) | 0.440 |
RCA, (%) | 468 (42) | 379 (42) | 89 (45) | |
Second generation DES, (%) | 508 (56) | 417 (56) | 91 (60) | 0.358 |
Successful CTO PCI, (%) | 889 (81) | 738 (81) | 151 (77) | 0.147 |
Complete revascularization, (%) | 772 (70) | 651 (72) | 121 (62) | 0.005 |
Platelet Reactivity: ADP Test Results by LTA | |
---|---|
Overall population | |
P2Y12 antagonist responders | n=905 |
Mean, (%) | 44±16 |
Median, (%) | 51 [15–68] |
HPR on clopidogrel therapy | n=196 |
Mean, (%) | 77±6 |
Median, (%) | 77 [71–90] |
HPR group on clopidogrel | |
“not switched” | n=114 |
Mean, (%) | 78±6 |
Median, (%) | 76 [71–92] |
“switched” | n=82 |
Mean, (%) | 46±17 |
Median, (%) | 49 [19–74] |
Values are mean±SD, number of patients (%) and median (%) [25th–75th percentiles]. ACS indicates acute coronary syndrome; ADP, adenosine diphosphate; CABG, coronary artery bypass grafting; CKD, chronic kidney disease; CTO, chronic total occlusion; DES, drug‐eluting stent; HPR, high platelet reactivity; LAD, left anterior descending artery; LTA, light transmission aggregometry; LVEF, left ventricular ejection fraction; MI, myocardial infarction; OPR, optimal platelet reactivity; PCI, percutaneous coronary intervention; RCA, right coronary artery.