Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
CoREST-mediated gene repression. CoREST forms a complex with HDAC1/2 and LSD1 to elicit transcriptional repression. A, CoREST binds to DNA sites through the SANT2 domain. HDAC1/2 deacetylates multiple acetylated lysine marks on the H3 tail. LSD1 demethylates monomethylated or dimethylated H3K4. B, The synergistic function of both chromatin modifying enzymes results in chromatin condensation thus repression of gene expression.
