Scheme 10.
a) diethyl ethoxymethylenemalonate, 3 h, 120 °C, 80%. (b) diphenyl ether, 1 h, reflux, 50%. (c) NaOH (2 N), ethanol, 2 h, reflux, 90%. (d) 2-fluoroethylamine/3-fluoropropylamine, trifluoroacetate, HATU, DIPEA, DMF, 12 h, rt.
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