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. 2020 Feb 21;25(4):971. doi: 10.3390/molecules25040971

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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K313 induces apoptosis in Nalm-6 and Daudi cells through the mitochondrial pathway. (A) Nalm-6 and Daudi cells were treated with K313 at indicated concentrations for 48 h and stained with JC-1 for 15 min. Loss of mitochondrial membrane potential was measured by FCM. (B) Columns represent the percentage of change of the MMP in Nalm-6 and Daudi cells. (C) After treatment with the vehicle or K313 for 24 h, the total protein lysates were detected by immunoblotting with antibodies. The expression levels of apotosis-related proteins in (D) Nalm-6 and (E) Daudi cells were quantified by Quantity One software. * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. control group.