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. 2020 Feb 20;25(4):950. doi: 10.3390/molecules25040950

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of pyrrole-imidazole (PI) polyamide targeting TGF-β1 or Mismatch PI polyamide on urinary excretions of protein and albumin in streptozotocin (STZ) diabetic rats. Diabetes was induced in male Wistar rats by single intraperitoneal injection of 60 mg/kg body weight of STZ. Control rats were intraperitoneally injected with 1 mL of 0.1% acetic acid. Urinary protein (A) and urinary albumin (B) were measured in 24-h urine collected in metabolic cages for 12 weeks. Five milligrams of PI polyamide targeting TGF-β1 dissolved in 1 mL of 0.1% acetic acid was intraperitoneally injected twice a week. Data are the mean ± SEM (n=5). * p < 0.05, ** p < 0.01 versus Control.