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. 2020 Feb 20;25(4):950. doi: 10.3390/molecules25040950

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Electron microscopic findings of kidney from control rats, STZ diabetic rats and STZ diabetic rats with pyrrole-imidazole (PI) polyamide targeting TGF-β1. Diabetes was induced in male Wistar rats by single intraperitoneal injection of 60 mg/kg body weight of STZ. Control rats were intraperitoneally injected with 1 mL of 0.1% acetic acid. Five milligrams of PI polyamide targeting TGF-β1 polyamide dissolved in 1 mL of 0.1% acetic acid was intraperitoneally injected twice a week for 3 months, and then the rats were sacrificed to removes their kidneys. The ultrastructure of the podocytes was observed under transmission electron microscopy. Scale bar indicates 1 μm. B–basement membrane, *–podocyte.