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. 2020 Feb 16;9(2):159. doi: 10.3390/antiox9020159

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Photomicrographs of anti-TLR-4-stained LV sections in: (A) Control rats showing the absence of immune reaction in cardiomyocytes cytoplasm and nuclei (arrow); (B) DOX-intoxicated rats showing very strong immune positivity; (C) CAR-treated rats showing mild immune positive reaction; (D) RES-treated rats showing strong positive immune reaction; (E) CAR/RES-treated rats showing very mild immunostaining; (F) LIPO-RES-treated rats showing moderate immune reaction and (G) CAR/LIPO-RES-treated rats showing marked decrease in TLR-4 immune reactivity. (H) Mean ± SEM of TLR-4 immunostaining in LV sections of different groups, (n = 6). *** p < 0.001 versus Control and ^### p < 0.001 versus DOX.