Scheme 4.
Synthesis of amides 18a and 18b. Reagents and conditions: (i) (1) Ac2O, K2CO3, acetone and (2) Pd(AcO)2, (o-Tol)3P, acrylic acid, Et3N, MeCN; (ii) (1) Deoxofluor®, PhCH3-CH2Cl2 and (2) i-PrNH2, Et3N-CH2Cl2; and (iii) H2SO4, MeOH.
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