Table 1.
Highlight of bioassay-guided isolation for NA inhibitors from GCL.
| Extract | Partitions | Fractions | Compounds | IC50 * | |
|---|---|---|---|---|---|
| NA-C. perfringensa | NA-H1N1 b | ||||
| MeOH extract | 4.48 µg/mL | 3.65 µg/mL | |||
| (17.98% mass) | Hexane extract | 11.04 µg/mL | 74.01 µg/mL | ||
| (14.96% w/w) | F1 (5.07%) | nd | nd | ||
| F2 (4.5%) | 39.42 µg/mL | nd | |||
| F3 (21.40%) | 73.84 µg/mL | 3.243 µg/mL | |||
| GC1 (2.20%) | nd | nd | |||
| F4 (21.28%) | 8.24 µg/mL | 289.4 µg/mL | |||
| GC2 (0.55%) | 81.74 µg/mL | 962.80 µg/mL | |||
| GC3 (0.24%) | 142.49 µg/mL | nd | |||
| F5 (21.45%) | 277.0 µg/mL | nd | |||
| EtOAc extract | 38.39 µg/mL | 48.36 µg/mL | |||
| (25.86% w/w) | F1 (4.80%) | nd | nd | ||
| F2 (26.39%) | 120.90 µg/mL | nd | |||
| F3 (14.21%) | 221.50 µg/mL | 146.49 µg/m | |||
| F4 (30.4%) | 16.18 µg/mL | 9.60 µg/mL | |||
| GC4 (0.49%) | 17.48 µg/mL | 26.29 µg/mL | |||
a IC50 of samples against C. perfringens-NA; b IC50 of samples against H1N1-NA; * nd; no detection.