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Dynamic residue network analysis: Average shortest path (L) results. Color key: black: WT holo, green: WT complexed with pyrimethamine, magenta: mutant holo, blue: mutant complexed with pyrimethamine. Shaded areas are zones of protein–ligand interactions. Lower threshold values are indicated by respective color-coded, dotted lines. Shaded areas are regions of ligand interaction within the active site.
