Table 2.
Patient characteristics in the I‐PICC study
| All VABHS patients aged 40–75 yearsa | I‐PICC eligible patientsb | I‐PICC declined patients | I‐PICC consented, not enrolled patientsc | I‐PICC enrolled patients | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Age (40–75 years): | 63.1 | 9.4 | 63.3 | 8.2 | 65.3 | 7.1 | 63.7 | 8.1 | 64.1 | 7.8 |
| n | % | n | % | n | % | n | % | n | % | |
| 20,959 | 6,245 | 433 | 492 | 408 | ||||||
| Sex | ||||||||||
| Female | 1,406 | 6.7 | 293 | 4.7 | 18 | 4.2 | 25 | 5.1 | 25 | 6.1 |
| Race | ||||||||||
| American Indian/Alaskan Native | 88 | 0.4 | 32 | 0.5 | 5 | 1.2 | 3 | 0.6 | 1 | 0.3 |
| Asian | 92 | 0.4 | 15 | 0.2 | 0 | 0.0 | 1 | 0.2 | 1 | 0.3 |
| Black/African American | 2,287 | 10.9 | 826 | 13.2 | 62 | 14.3 | 67 | 13.6 | 50 | 12.3 |
| Native Hawaiian/Pacific Islander | 43 | 0.2 | 11 | 0.2 | 1 | 0.2 | 1 | 0.2 | 0 | 0.0 |
| White | 17,548 | 83.7 | 5,053 | 80.9 | 347 | 80.1 | 407 | 82.7 | 341 | 83.6 |
| Multiracial | 107 | 0.5 | 30 | 0.5 | 2 | 0.5 | 2 | 0.4 | 4 | 1.0 |
| Unknown/declined | 794 | 3.8 | 278 | 4.5 | 16 | 3.7 | 11 | 2.2 | 11 | 2.7 |
| Ethnicity | ||||||||||
| Hispanic or Latino | 527 | 2.5 | 150 | 2.4 | 13 | 3.0 | 7 | 1.7 | 8 | 2.0 |
| Smoking status | ||||||||||
| Smoker | 7,140 | 34.1 | 2,537 | 40.6 | 147 | 33.9 | 192 | 39.0 | 137 | 33.6 |
| ACC/AHA risk criteriad | ||||||||||
| Existing CVD | 6,339 | 30.2 | 1,038 | 16.6 | 98 | 22.6 | 102 | 20.7 | 98 | 24.0 |
| LDL‐C ≥190 mg/dL | 1,944 | 9.3 | 242 | 3.9 | 17 | 3.9 | 12 | 2.4 | 11 | 2.7 |
| Diabetes | 6,329 | 30.2 | 1,205 | 19.3 | 111 | 25.6 | 101 | 20.5 | 98 | 24.0 |
| 10‐year CVD risk ≥ 7.5% | 16,764 | 80.0 | 5,871 | 94.0 | 413 | 95.4 | 463 | 94.1 | 367 | 90.0 |
Patient samples derived during the study recruitment and enrollment period between August 1, 2016, and July 17, 2018. Individual patients may be included in multiple samples.
ACC/AHA, American College of Cardiology/American Heart Association; CVD, cardiovascular disease; I‐PICC, Integrating Pharmacogenetics in Clinical Care; LDL‐C, low‐density lipoprotein cholesterol; VABHS, Veterans Affairs Boston Healthcare System.
This sample matched on age and existence of an active relationship with a primary care provider during period of study recruitment and enrollment. Of these, 11,766 (56%) had been prescribed a statin prior to the study period.
Eligible sample based on I‐PICC Study eligibility criteria (age, no history of statin use, ACC/AHA risk criteria,22 receiving care at VABHS for at least 6 months, and active relationship with a primary care provider) at any time during the period of study recruitment and enrollment.
By design, patients consent to be considered for enrollment but are only enrolled if/when their provider signs an order for a pharmacogenetic test to be performed on an existing clinical blood sample.
Patients may satisfy any one of multiple ACC/AHA risk criteria.