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. 2019 Nov 20;13(2):301–308. doi: 10.1111/cts.12710

Figure 2.

Figure 2

(a) The percentage of group 5 subjects (3 months to 7 years; < 50 kg) achieving the target plasma meropenem concentration as a function of the bacterial minimum inhibitory concentration (MIC) at three dosage regimens (all with 0.5 drug infusion time unless otherwise indicated): US Food and Drug Administration (FDA; current approved label): 20 mg/kg Q8h; HiDose: 40 mg/kg Q8h; and infusion: 20 mg/kg Q8h, infused over 3 hours; Q6h: 20 mg/kg Q6h. (b) The percentage of group 6 subjects (> 50 kg) achieving the target plasma meropenem concentration as a function of the bacterial MIC at three dosage regimens (all with 0.5 drug infusion time unless otherwise indicated): FDA (current approved label): 1 g Q8h; HiDose: 2 g Q8h; and infusion: 1 g Q8h, infused over 3 h; Q6h: 1 g Q6h. PD, pharmacodynamic.