Table 1.
Cytotoxicity of compounds 1–3 after incubation for 24 h.
MM Cells % Alive | PBMC % Alive | ||||
---|---|---|---|---|---|
cpd. | conc. | NCI-H929 | OPM-2 | U266 | |
1 | 50 µM | 48.2 ± 10.9 | 81.1 ± 4.7 | 75.1 ± 6.4 | 85.6 ± 1.2 |
25 µM | 80.5 ± 5.9 | 93.2 ± 3.7 | 90.2 ± 4.1 | 96.4 ± 0.1 | |
2 | 50 µM | 27.9 ± 12.2 | 71.0 ± 11.2 | 56.3 ± 21.4 | 84.0 ± 3.0 |
25 µM | 87.7 ± 4.9 | 86.2 ± 8.6 | 79.4 ± 20.2 | 94.7 ± 1.8 | |
3 | 50 µM | 10.3 ± 2.8 | 19.7 ± 5.7 | 12.9 ± 3.5 | 6.1 ± 1.5 |
25 µM | 52.9 ± 7.1 | 63.8 ± 12 | 89.3 ± 3.2 | 86.5 ± 2.7 |