Table 2.
Cytotoxicity of compounds 1–3 after incubation for 48 h.
MM Cells % Alive | PBMC % Alive | ||||
---|---|---|---|---|---|
cpd. | conc. | NCI-H929 | OPM-2 | U266 | |
1 | 50 µM | 13.2 ± 2.4 | 67.3 ± 6.7 | 35.5 ± 6.7 | 74.9 ± 1.2 |
25 µM | 70.2 ± 4.3 | 93.1 ± 2.4 | 81.0 ± 5.9 | 94.6 ± 0.2 | |
2 | 50 µM | 17.4 ± 7.3 | 51.7 ± 8.9 | 62.1 ± 0.4 | 76.1 ± 2.1 |
25 µM | 63.9 ± 10.6 | 84.6 ± 1.0 | 90.2 ± 1.7 | 92.7 ± 1.7 | |
3 | 50 µM | 6.6 ± 2.2 | 9.6 ± 2.8 | 9.1 ± 3.8 | 4.6 ± 0.1 |
25 µM | 18.9 ± 3.3 | 43.4 ± 9.3 | 66.8 ± 9.5 | 76.2 ± 1.8 |