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. 2020 Feb 18;25(4):902. doi: 10.3390/molecules25040902

Figure 1.

Figure 1

Pharmacological effects of Epigallocatechin-3-Gallate (EGCG) on the cardiac sodium channel Nav1.5. (a) Chemical structure of EGCG. (b) Time course recording of the INa current in the presence of various concentrations of EGCG. The dashed line represents the zero current. (c) Representative traces of INa currents in the presence of various EGCG concentrations at holding potential −100 mV. (d) Dose-response effects of EGCG on the inhibition of INa peak currents (holding potential = −100 mV, IC50 = 31.2 ± 3.6 µM, n = 8). (e) Representative traces of INa currents in the presence of various EGCG concentrations at holding potential −80 mV. (f) Dose-response effects of EGCG on the inhibition of INa peak currents (holding potential = −80 mV, IC50 = 2,1 ± 1 µM, n = 5–7).