Table 1.
Effect of EGCG on the gating properties of Nav1.5 channels.
| Control | 30 µM EGCG | |
|---|---|---|
| Peak current densities at −20 mV (pA/pF) | −146.2 ± 17.8; n = 12 | −64.3 ± 7.3 ***; n = 12 |
| V1/2 activation (mV) | −27.4 ± 0.8; n = 12 | −27.4 ± 1; n = 12 |
| Activation slope (mV) | 6.7 ± 0.2; n = 12 | 8 ± 2 ***; n = 12 |
| Time to peak at −20 mV (ms) | 1.12 ± 0.02; n = 12 | 1.16 ± 0.03; n = 12 |
| V1/2 inactivation (mV) | −79.4 ± 1.3; n = 13 | −87 ± 0.9 ***; n = 13 |
| Inactivation slope (mV) | 5 ± 0.2; n = 13 | 5.5 ± 0.2 *; n = 13 |
| t1/2 inactivation at −20 mV (ms) | 0.43 ± 0.02; n = 12 | 0.56 ± 0.03 **; n = 12 |
| Recovery from fast inactivation (ms) | ||
| τfast,1 | 5.1 ± 0.9; n = 5 | 24.3 ± 7.1 *; n = 5 |
| τfast,2 | 110 ± 28.6; n = 5 | 233.7 ± 37.6 *; n = 5 |
* p < 0.05, ** p < 0.01, *** p < 0.001.