Table 1.
Examples of proteins with multivalent post-translational modification (PTM) recognition including a methyl-lysine (Kme) domain.
| Protein | UniProt Accession | Domains | PTM Recognition | PDB ID | Disease Relevance | References |
|---|---|---|---|---|---|---|
| SETDB1 | Q15047 | Triple Tudor | H3K9me2/3K14ac | 6BHD, 6BHE, 6BHI | Huntington’s, Cancer – Breast, Liver, Prostate |
[3,25,26,27,28,29] |
| UHRF1 | Q96T88 | PHD, Tandem Tudor | H3(N-terminus)K9me3 | 4GY5 | Cancer – Breast, Lung, Prostate, Liver | [4,30,31,32,33,34,35] |
| TRIM24 | O15164 | PHD, Bromo | H3K9K23ac | 3O34 | Cancer – Breast, Liver, Lung, Colon | [5,36,37,38,39] |
| TRIM33 | Q9UPN9 | PHD, Bromo | H3K9me3K14ac, H3K9me3K14acK18ac | 3U5N, 3U5O | Cancer – Liver, Pancreatic, Leukemia | [6,37,40,41] |
| PHF8 | Q9UPP1 | PHD, Jumonji | H3K4me3K9me2 | 3KV4 | Cancer – Prostate, Lung, Breast, Gastric | [7,42,43,44,45,46] |
| RAG2 | P55895 | PHD | H3R2meK4me3 | 2V85 | Lymphoid tumors and immunological disorders | [8,47,48] |
| 53BP1 | Q12888 | Tandem Tudor | *p53K381acK382me2 | 4X34 | Cancer – Breast, Ovarian, Colon | [9,49,50,51,52] |
*Non-histone PTMs.