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. 2020 Feb 18;25(4):893. doi: 10.3390/molecules25040893

Table 2.

IC50 values of β-lapachone and derivatives in different study models.

Compound 2D Structure IC50 Study Model References
Lapachol graphic file with name molecules-25-00893-i009.jpg 16.04–72.3 µM Human chronic myelogenous leukemia (K562, Lucena), Burkitt’s lymphoma (Daudi), Breast cancer (MCF-7, SK-BR3) [110,111]
ß-lapachone graphic file with name molecules-25-00893-i010.jpg 0.03–70.13 µM Lung cancer cells (A549 cell line); Tongue squamous cell carcinoma (HSC-3, SCC4, SCC9, SCC15, SCC25), hepatocellular carcinoma (HEPG2), HL-60, K562, Gastric adenocarcinoma (AGP-01, ACP-02, ACP-03), colon adenocarcinoma (HT-29, HCT-116). [112,113]
α-lapachone graphic file with name molecules-25-00893-i011.jpg 38–69 µM K562, Lucena, Daudi, MCF-7 [111]
3-iodo-ß-lapachone graphic file with name molecules-25-00893-i012.jpg 0.02–5.61 µM Tongue squamous cell carcinoma (HSC-3, SCC4, SCC9, SCC15, SCC25), hepatocellular carcinoma (HEPG2), HL-60, K562, Gastric adenocarcinoma (AGP-01, ACP-02, ACP-03), colon adenocarcinoma (HT-29, HCT-116). [113]
3-I-α-lapachone graphic file with name molecules-25-00893-i013.jpg 0.77–14.65 µM
naphtho[2,1-d]oxazole-4,5-diones graphic file with name molecules-25-00893-i014.jpg 4.6–20 µM * Lung cancer cells (A549 cell line) [112]

* IC50 values range for all derivatives shown in reference [112].