Table 1.
Mean Values Grouped by Injury Severity at 1, 28, and 90 DPI
| Metric | Days post-injury | Sham | Mild | Moderate | Severe |
|---|---|---|---|---|---|
| BBB score | 1 | 19.4 (1.7) | 10.1 (2.8) | 7.0 (3.0) | 1.9 (1.4) |
| 30 | 21.0 (0.0) | 15.6 (2.9) | 15.0 (3.0) | 8.4 (1.9) | |
| 90 | 21.0 (0.0) | 19.3 (3.4) | 17.4 (2.3) | 10.6 (1.9) | |
| ADC|| | 1 | 1.72 (0.16) | 1.47 (0.14) | 1.32 (0.20) | 1.01 (0.23) |
| 30 | 1.87 (0.33) | 1.50 (0.18) | 1.47 (0.37) | 1.20 (0.24) | |
| 90 | 1.46 (0.15) | 1.34 (0.23) | 1.30 (0.45) | 0.97 (0.12) | |
| AWF | 1 | 0.49 (0.09) | 0.48 (0.08) | 0.46 (0.07) | 0.45 (0.06) |
| 30 | 0.47 (0.06) | 0.43 (0.09) | 0.38 (0.05) | 0.33 (0.04) | |
| 90 | 0.50 (0.04) | 0.37 (0.07) | 0.36 (0.07) | 0.39 (0.12) | |
| Cord CSA | 1 | 6.32 (1.07) | 6.57 (0.73) | 7.45 (0.78) | 6.49 (0.95) |
| 30 | 6.20 (0.81) | 4.91 (0.85) | 5.45 (1.16) | 3.83 (1.08) | |
| 90 | 6.49 (0.82) | 3.73 (1.20) | 3.80 (0.71) | 2.89 (1.23) | |
| Hemorrhage area | 1 | 0.05 (0.09) | 0.28 (0.24) | 0.25 (0.22) | 0.12 (0.12) |
| 30 | 0.04 (0.04) | 0.13 (0.11) | 0.13 (0.07) | 0.04 (0.04) | |
| 90 | 0.10 (0.12) | 0.09 (0.09) | 0.07 (0.06) | 0.01 (0.02) |
Values indicate mean (SD), and all MRI metrics are from a single slice at the lesion epicenter. Units are: ADC|| = μm2/ms; AWF = fraction; area = mm2.
dpi, days post-injury; BBB, Basso, Beattie, and Bresnahan; ADC||, parallel diffusivity from imaged-based DDE; AWF, axonal water fraction; CSA, cross-sectional area; SD, standard deviation; MRI, magnetic resonance imaging;