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. 2020 Jan 23;9(2):96. doi: 10.3390/antiox9020096

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of (–)-epicatechin on the nitric oxide synthase (NOS) activity (a) and gene expression of neuronal nNOS (b), inducible iNOS (c), endothelial eNOS (d), Nrf2 (e) and PPAR-γ (f) in the aorta of borderline hypertensive rats. The values represent the mean ± SEM; n = 6–7 per group. ^x p < 0.05 vs. C7 group, ⁺ p < 0.05 vs. Epi group. Abbreviations: C7: seven-week-old control group, C9: nine-week-old control group, Epi: (–)-epicatechin group, PE: (–)-epicatechin post-treatment group, Nrf2: nuclear factor erythroid 2-related factor 2, PPAR-γ: peroxisome proliferator-activated receptor gamma.