Table 1.
Postinjury Bolus Experimental Matrix and Injury Parameters (Mean ± SD)
| Caffeine bolusa |
Shamb |
Mild |
Moderate |
Severe |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Time (sec) | Dose (mg/kg) | n | Weight (g) | FPI (atm) | n | Weight (g) | FPI (atm) | n | Weight (g) | FPI (atm) | n | Weight (g) | FPI (atm) |
| 10 | 0.0 | 8 | 400 ± 12 | 0 ± 0 | 8 | 373 ± 17 | 0.60 ± 0.03 | 8 | 373 ± 9 | 1.90 ± 0.05 | 12 | 371 ± 16 | 3.01 ± 0.07 |
| 12.5 | — | — | — | — | — | — | — | — | — | 12 | 380 ± 12 | 2.98 ± 0.05 | |
| 25.0 | 6 | 404 ± 7 | 0 ± 0 | 8 | 378 ± 15 | 0.62 ± 0.03 | 8 | 373 ± 16 | 1.90 ± 0.08 | 16 | 368 ± 11 | 2.98 ± 0.04 | |
| 50.0 | — | — | — | — | — | — | — | — | — | 12 | 375 ± 14 | 3.03 ± 0.05 | |
| 90 | 25.0 | — | — | — | — | — | — | — | — | — | 14 | 378 ± 12 | 3.01 ± 0.07 |
All rats in this study received caffeine in their drinking water (0.3 g/L) for 3 weeks before FPI.
a
Postinjury bolus delivered IP in 1 mL/kg saline.
b
Heavy rats were assigned to the Sham FPI group.
FPI, fluid percussion injury.