Table 3.
Preinjury Caffeine Bolus Experimental Matrix and Injury Parameters (mean ± SD)
| Preinjury |
Severe FPI |
|||
|---|---|---|---|---|
| Chronic caffeinea | Acute | n | Weight (g) | FPI (atm) |
| 0 g/L | None | 22 | 367 ± 20 | 2.80 ± 0.24 |
| Bolusb | 20 | 368 ± 14 | 2.88 ± 0.21 | |
| 0.3 g/L | None | 20 | 366 ± 18 | 2.80 ± 0.26 |
| Bolusb | 20 | 370 ± 16 | 2.83 ± 0.23 | |
| Withdrawc | 20 | 365 ± 18 | 2.84 ± 0.24 | |
a
Chronic caffeine: administered ad libitum in drinking water for 3 weeks before FPI.
b
Bolus: 25 mg/kg, administered IP in 1 mL/kg saline 1 hour before FPI.
c
Withdraw: 36-hour caffeine withdrawal before FPI.