Table 1.

Pharmacokinetic Parameters for Malabaricone C Administered Orally or Intravenously

Pharmacokinetic parameters	i.v.	Oral
tmax (min)	2.9	7.8
Cmax (mg/L)	2.56 ± 0.60	0.05 ± 0.01
AUC0–t (mg/mL/min)	7.91 ± 1.86	0.7 ± 0.14
CL (L/kg/min)	0.532 ± 0.15	0.27 ± 0.13
t1/2 (min)	4.73 ± 1.86	14.65 ± 2.63

Mice (n = 10) were given a single Mal C dose intravenously (10 mg/kg, i.v.) or orally (200 mg/kg, p.o.), and plasma concentrations of Mal C determined by high-performance liquid chromatography 5–60 min following drug administration. Concentration values were fitted to a one-compartmental model to determine key pharmacokinetic parameters.

AUC_0–t, area under the curve of a plasma concentration versus time profile; CL, total plasma clearance; C_max, maximum concentration; i.v., intravenous; Mal C, malabaricone C; p.o., per os; t_max, time to reach C_max; t_1/2, elimination half-life.