Table 1.
Baseline Demographics of 205 Episodes of Enterococcal Bacteremia
| All Patients | No IDC | IDC | ||
|---|---|---|---|---|
| Variable | (n = 205) | (n = 74) | (n = 131) | P Value |
| Age, median (IQR), y | 59 (23) | 59 (15) | 59 (27) | .54 |
| Male, No. (%) | 107 (52) | 36 (49) | 71 (54) | .44 |
| White, No. (%) | 112 (55) | 44 (60) | 68 (52) | .23 |
| IVDU, No. (%) | 10 (5) | 1 (1) | 9 (7) | .10 |
| COPD, No. (%) | 40 (20) | 11 (15) | 29 (22) | .21 |
| CAD, No. (%) | 40 (20) | 14 (19) | 26 (20) | .87 |
| CHF, No. (%) | 54 (26) | 17 (23) | 37 (28) | .41 |
| Connective tissue disease, No. (%) | 8 (4) | 3 (4) | 5 (4) | 1.00 |
| Diabetes, No. (%) | 73 (36) | 33 (45) | 40 (30) | .04 |
| Hypertension, No. (%) | 118 (58) | 42 (57) | 76 (58) | .86 |
| CKD, No. (%) | 58 (28) | 24 (32) | 34 (26) | .32 |
| Hemodialysis, No. (%) | 26 (13) | 8 (11) | 18 (14) | .54 |
| PVD, No. (%) | 13 (6) | 7 (10) | 6 (5) | .17 |
| Malignancy, No. (%) | 47 (23) | 20 (27) | 27 (20) | .29 |
| Cirrhosis, No. (%) | 19 (9) | 6 (8) | 13 (10) | .67 |
| Hepatitis, No. (%) | 15 (7) | 5 (7) | 10 (8) | 1.00 |
| HIV, No. (%) | 4 (2) | 1 (1) | 3 (2) | 1.00 |
| Immunocompromised, No. (%) | 52 (25) | 16 (22) | 36 (27) | .35 |
| • Hematologic malignancy | 16 (8) | 6 (8) | 10 (8) | .83 |
| • Solid organ transplantation | 24 (12) | 7 (10) | 17 (13) | |
| • Immunosuppressive agents | 11 (5) | 3 (4) | 8 (6) | |
| • CD4 <200 | 1 (0.5) | 0 (0) | 1 (1) | |
| Charlson comorbidity index, median (IQR) | 3 (4) | 2 (4) | 3 (3) | .84 |
| Hospitalization <30 d before bacteremia | 107 (53) | 37 (50) | 70 (53) | .64 |
| Invasive procedure 30 d before bacteremia | 62 (30) | 23 (31) | 39 (30) | .84 |
| Bacteremia diagnosed ≥48 h after admission | 172 (84) | 57 (77) | 115 (88) | .04 |
| Admitting service | ||||
| • ICU | 58 (28) | 21 (28) | 37 (28) | .24 |
| • Medical | 97 (48) | 30 (41) | 67 (51) | |
| • Surgical | 29 (14) | 15 (20) | 14 (11) | |
| • Transplant/IC | 21 (10) | 8 (11) | 13 (10) | |
| ICU placement within 72 h | 109 (53) | 40 (54) | 69 (53) | .85 |
| Symptoms within 24 h of bacteremia | ||||
| • Fever | 105 (51) | 42 (57) | 63 (48) | .23 |
| • Hypotension | 76 (37) | 28 (38) | 48 (37) | .86 |
| • Leukocytosis | 116 (57) | 47 (64) | 69 (53) | .13 |
| • Neutropenia | 12 (6) | 2 (3) | 10 (8) | .22 |
| • AKI | 67 (32) | 30 (40) | 37 (28) | .07 |
| Mechanical ventilation | 44 (22) | 17 (23) | 27 (21) | .69 |
| Enterococcus species | ||||
| • Enterococcus faecalis | 133 (65) | 49 (66) | 84 (64) | .88 |
| • Enterococcus faecium | 68 (33) | 24 (33) | 44 (34) | |
| • Other | 4 (2) | 1 (1) | 3 (2) | |
| Vancomycin-resistant Enterococcus | 67 (33) | 24 (32) | 43 (33) | .95 |
| Time from admission to bacteremia, median (IQR), d | 5 (19) | 5 (16) | 6 (19) | .05 |
Abbreviations: AKI, acute kidney injury; CAD, coronary artery disease; CHF, congestive heart failure; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IC, immunocompromised; ICU, intensive care unit; IDC, infectious diseases consultation; IQR, interquartile range; IVDU, intravenous drug user; PVD, peripheral vascular disease.