Table 2.
Parameters of glycaemic response in participants classified as having either a monophasic or complex glucose curve shape at control visit and treatments with 50 and 400 mg of Enzogenol®.
| Parameters of Glycaemic Response | Monophasic Group | Complex Group | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control Paired to 50 mg of Enzogenol® | 50 mg of Enzogenol® | p | Control Paired to 400 mg of Enzogenol® | 400 mg of Enzogenol® | p | Control Paired to 50 mg of Enzogenol® | 50 mg of Enzogenol® | p | Control Paired to 400 mg of Enzogenol® | 400 mg of Enzogenol® | p | |
| n | 12 | - | 11 | - | 13 | - | 9 | - | ||||
| Gender (M/F) | 3/9 | - | 3/8 | - | 7/6 | - | 5/4 | - | ||||
| Mean glucose iAUC (mmol/L·min) | 335.4 ± 34.0 † | 241.3 ± 20.2 | 0.034 * | 353.6 ± 31.5 ‡ | 249.3 ± 25.4 | 0.012 * | 222.7 ± 26.6 † | 238.4 ± 32.7 | 0.392 | 233.5 ± 36.4 ‡ | 219.1 ± 19.5 | 0.614 |
| Mean %PG | 44.9 ± 8.3 | 28.9 ± 3.8 | 0.083 | 47.5 ± 8.6 | 31.4 ± 7.9 | 0.010 * | 43.4 ± 5.9 | 28.7 ± 8.2 | 0.012* | 47.3 ± 7.2 | 27.7 ± 5.4 | 0.025 * |
| Mean time to glucose peak (min) | 35.0 ± 2.8 | 32.5 ± 2.5 | 0.504 | 35.5 ± 3.0 | 32.7 ± 4.0 | 0.441 | 28.8 ± 2.7 | 28.8 ± 4.0 | 1.000 | 28.3 ± 3.0 | 26.7 ± 4.9 | 0.729 |
| Mean glucose peak value (mmol/L) | 8.8 ± 0.3† | 8.3 ± 0.4 | 0.177 | 8.9 ± 0.3‡ | 7.9 ± 0.3 | 0.025 * | 7.7 ± 0.3 † | 8.2 ± 0.4 | 0.315 | 7.8 ± 0.3 ‡ | 8.0 ± 0.3 | 0.531 |
| Mean 2hPG (mmol/L) | 6.6 ± 0.2 | 6.3 ± 0.2 | 0.171 | 6.7 ± 0.3 | 6.1 ± 0.3 | 0.027 * | 6.3 ± 0.2 | 5.9 ± 0.3 | 0.149 | 6.5 ± 0.3 | 6.1 ± 0.2 | 0.224 |
* Significant difference between control and 50 or 400 mg of Enzogenol® within each glucose curve shape group (p < 0.05); † Significant difference in control visit values between monophasic and complex glucose curve shape groups at 50 mg of Enzogenol® (p < 0.05); ‡ Significant difference in control visit values between monophasic and complex glucose curve shape groups at 400 mg of Enzogenol® (p < 0.05); Abbreviations: iAUC: incremental area under the curve of postprandial glucose; %PG: percentage increment of postprandial glucose; 2hPG: 2h postprandial glucose at 120 min of the oral glucose tolerance test (OGTT).