Table 2.
Effects of 5-CQA on mRNA expression in the mouse brain.
| Gene Name and Brain Region | WT | APP/PS2 | APP/PS2 + 5-CQA | |
|---|---|---|---|---|
| Amyloid processing | ||||
| ADAM10 | Cortex | 0.92 ± 0.04 | 1.00 ± 0.05 | 0.93 ± 0.04 |
| Hippocampus | 0.89 ± 0.02 | 1.00 ± 0.04 | 0.95 ± 0.04 | |
| APP (human) | Cortex | N.T. | 1.00 ± 0.09 | 1.20 ± 0.06 |
| Hippocampus | N.T. | 1.00 ± 0.09 | 1.18 ± 0.07 | |
| BACE1 | Cortex | 0.91 ± 0.04 | 1.00 ± 0.03 | 0.94 ± 0.04 |
| Hippocampus | 0.87 ± 0.03 | 1.00 ± 0.04 | 1.08 ± 0.05## | |
| Amyloid degrading | ||||
| IDE | Cortex | 0.97 ± 0.04 | 1.00 ± 0.03 | 1.02 ± 0.05 |
| Hippocampus | 1.01 ± 0.04 | 1.00 ± 0.03 | 1.01 ± 0.02 | |
| NEP | Cortex | 1.06 ± 0.17 | 1.00 ± 0.13 | 1.17± 0.20 |
| Hippocampus | 0.91 ± 0.05 | 1.00 ± 0.05 | 1.02 ± 0.05 | |
| Amyloid transport protein | ||||
| LRP-1 | Cortex | 0.93 ± 0.04 | 1.00 ± 0.04 | 1.03 ± 0.02 |
| Hippocampus | 0.92 ± 0.03 | 1.00 ± 0.04 | 1.23 ± 0.09*, ## | |
| RAGE | Cortex | 1.43 ± 0.11* | 1.00 ± 0.10 | 1.16 ± 0.09 |
| Hippocampus | 1.19 ± 0.08 | 1.00 ± 0.10 | 1.27 ± 0.09 | |
Values represent the relative gene expression levels for seven mice (means ±SEM) (APP/PS2 = 1). Differences were considered significant at p < 0.05. *: p < 0.05 vs. APP/PS2, #: p < 0.05, ##: p <0.01 vs. WT (Bonferroni’s post-hoc test). N.T., not tested; ADAM10, a disintegrin and metallopeptidase domain 10; BACE1, beta-site APP cleaving enzyme 1; IDE, insulin-degrading enzyme; NEP, neprilysin; LRP-1, low-density lipoprotein receptor-related protein 1; RAGE, receptor for advanced glycation end products.