Table 2.

Challenge results of eliciting-dose reaction to open apple challenge over time.

	Open Food Challenge (OFC) with Apple
	Negative or Positive with Eliciting-Dose Reaction
Months	Before Start AIT	Dose Reaction	After 12 Months AIT	Dose Reaction	After 24 Months AIT	Dose Reaction
Patient
1	Neg		Pos	2	Neg
2	Neg		Neg		Neg
3	Pos	2	Pos	1	Pos	9
4	Pos	1	Pos	1	Pos	1
5	Pos	2	Neg		Neg
6	Neg		Pos	8	Pos	8
7	Pos	1	Pos	9	Neg
8	Pos	1	Pos	9	Pos	6

Pos = positive OFC with apple, Neg = negative OFC with apple (no reaction on all doses). Dose reaction for microwave apple: dose 1, ‘chew and spit’ phase of 5 g apple, doses 2, 3 and 4 consisted of a ‘chew and swallow’ phase with doses of 5, 10 and 15 g apple, respectively. Dose reactions of unprocessed apple: dose 5, ‘chew and spit’ phase of 5 g apple; doses 6, 7 and 8 consisted of a ‘chew and swallow’ phase with doses of 5, 10 and 15 g apple, respectively. Dose 9 = remainder of the apple.