Table 5.
Risk of dyslipidemia depending on the coffee intake and genotype in ADORA gene family in female.
| Genes | Alleles | Coffee Intake | Healthy | Dyslipidemia | Adjusted Model 1 | ||
|---|---|---|---|---|---|---|---|
| SNPs | (n = 1215) | (n = 1312) | Odds ratios (95% CI) | p | p 2 | ||
| ADORA1 | |||||||
| rs10800899 | GG | <1 cup/d | 392 (29.47) | 374 (35.93) | 1 | 0.2012 | |
| ≥1 cup/d | 537 (40.38) | 366 (35.16) | 0.789 (0.643–0.968) | 0.0233 | |||
| AG/AA | <1 cup/d | 179 (13.46) | 167 (16.04) | 0.989 (0.761–1.286) | 0.9356 | ||
| ≥1 cup/d | 222 (16.69) | 134 (12.87) | 0.705 (0.537–0.924) | 0.0115 | |||
| rs6701725 | GG | <1 cup/d | 393 (29.55) | 367 (35.25) | 1 | 0.3393 | |
| ≥1 cup/d | 520 (37.10) | 346 (33.24) | 0.784 (0.636–0.966) | 0.0225 | |||
| AG/AA | <1 cup/d | 178 (13.38) | 174 (16.71) | 1.031 (0.794–1.339) | 0.8196 | ||
| ≥1 cup/d | 239 (17.97) | 154 (14.79) | 0.758 (0.585–0.982) | 0.0356 | |||
| rs10800901 | AA | <1 cup/d | 180 (13.53) | 172 (16.52) | 1 | 0.3401 | |
| ≥1 cup/d | 210 (15.79) | 160 (15.37) | 0.891 (0.656–1.210) | 0.4956 | |||
| GA/GG | <1 cup/d | 391 (29.40) | 369 (35.45) | 1.008 (0.777–1.309) | 0.9504 | ||
| ≥1 cup/d | 549 (41.28) | 340 (32.66) | 0.727 (0.560–0.944) | 0.0168 | |||
| ADORA2A | |||||||
| rs5760423 | GG | <1 cup/d | 194 (14.59) | 173 (16.62) | 1 | 0.3188 | |
| ≥1 cup/d | 224 (16.84) | 149 (14.31) | 0.836 (0.617–1.134) | 0.2497 | |||
| TG/TT | <1 cup/d | 377 (28.35) | 368 (35.35) | 1.124 (0.869–1.456) | 0.3736 | ||
| ≥1 cup/d | 535 (40.23) | 351 (33.72) | 0.829 (0.641–1.073) | 0.1539 | |||
| ADORA2B | |||||||
| rs17715109 | GG | <1 cup/d | 508 (38.20) | 486 (46.69) | 1 | 0.7766 | |
| ≥1 cup/d | 671 (50.45) | 461 (44.28) | 0.795 (0.662–0.956) | 0.0146 | |||
| TG/TT | <1 cup/d | 63 (4.74) | 55 (5.28) | 0.903 (0.608–1.339) | 0.6107 | ||
| ≥1 cup/d | 88 (6.62) | 39 (3.75) | 0.500 (0.332–0.754) | 0.0009 | |||
| rs2779212 | TT | <1 cup/d | 343 (25.79) | 335 (32.18) | 1 | 0.8210 | |
| ≥1 cup/d | 421 (31.65) | 301 (28.91) | 0.839 (0.671–1.049) | 0.1226 | |||
| CT/CC | <1 cup/d | 228 (17.14) | 206 (19.79) | 0.943 (0.735–1.210) | 0.6469 | ||
| ≥1 cup/d | 338 (25.41) | 199 (19.12) | 0.645 (0.506–0.823) | 0.0004 | |||
| ADORA3 | |||||||
| rs3393 | CC | <1 cup/d | 179 (13.46) | 163 (15.66) | 1 | 0.9277 | |
| ≥1 cup/d | 247 (18.57) | 157 (15.08) | 0.776 (0.572–1.053) | 0.1035 | |||
| TC/TT | <1 cup/d | 392 (29.47) | 378 (36.31) | 1.053 (0.809–1.370) | 0.7011 | ||
| ≥1 cup/d | 512 (38.50) | 343 (32.95) | 0.806 (0.618–1.051) | 0.1109 | |||
| rs2786967 | AA | <1 cup/d | 486 (36.54) | 444 (42.65) | 1 | 0.0308 | |
| ≥1 cup/d | 617 (46.39) | 411 (39.48) | 0.818 (0.676–0.989) | 0.0384 | |||
| GA/GG | <1 cup/d | 85 (6.39) | 97 (9.32) | 1.306 (0.939–1.816) | 0.1125 | ||
| ≥1 cup/d | 142 (10.68) | 89 (8.55) | 0.737 (0.542–1.002) | 0.0515 | |||
1 Adjusted for age, income, education, drinking and smoking behavior, energy intake, BMI, menopause, treatment of female hormone, Hypertension. 2 p for interaction.