Table 3.
Associations between genetically predicted iron status, based on three primary SNPs, and liver cancer in sensitivity analyses.
| SNP (Gene) or Method | Serum Iron | Transferrin Saturation | Ferritin | Transferrin | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| rs1800562 (HFE) | 6.65 (2.78, 15.9) | 2.02 × 10−5 | 2.94 (1.79, 4.82) | 2.02 × 10−5 | 21.0 (5.18, 85.4) | 2.02 × 10−5 | 0.27 (0.15, 0.50) | 2.02 × 10−5 |
| rs1799945 (HFE) | 1.01 (0.32, 3.16) | 0.99 | 1.01 (0.40, 2.56) | 0.99 | 1.03 (0.04, 28.3) | 0.99 | 0.98 (0.15, 6.50) | 0.99 |
| rs855791 (TMPRSS6) | 1.54 (0.65, 3.64) | 0.32 | 1.51 (0.67, 3.42) | 0.32 | 4.14 (0.24, 70.3) | 0.32 | 0.17 (0.01, 5.82) | 0.32 |
| IVW-Random effects | 2.45 (0.81, 7.45) | 0.11 | 2.11 (1.16, 3.83) | 0.01 | 10.9 (2.44, 48.6) | 2.00 × 10−3 | 0.30 (0.17, 0.53) | 2.99 × 10−5 |
| Weighted median | 2.08 (0.97, 4.47) | 0.06 | 2.14 (1.39, 3.31) | 1.00 × 10−3 | 12.1 (3.24, 45.2) | 3.43 × 10−4 | 0.30 (0.17, 0.53) | 3.31 × 10−5 |
| MR-Egger | 49.0 (5.64, 424) | 4.17 × 10−4 | 4.36 (1.87, 10.1) | 1.00 × 10−3 | 46.4 (5.47, 394) | 4.38 × 10−4 | 0.28 (0.11, 0.70) | 7.00 × 10−3 |
| Heterogeneity (I2) | 76 (23, 93) | 0.01 | 58 (0, 88) | 0.09 | 38 (0, 81) | 0.20 | 0 (0, 90) | 0.43 |
| Pleiotropy (Intercept) | NA | 5.00 × 10−3 | NA | 0.06 | NA | 0.11 | NA | 0.76 |
CI indicates confidence interval; IVW, inverse-variance weighted; NA, Not Available; OR, odds ratio; SNP, single nucleotide polymorphism.