Table 2.
Measures of body weight, kidney weight, and blood pressure in 16-week-old male offspring exposed to high-fat diet (HFD) and 5-aminoimidazole-4-carboxamide riboside (AICAR) in pregnancy or lactation.
| Groups | Control | HFD | AICAR/P | HFD + AICAR/L | HFD + AICAR/P |
|---|---|---|---|---|---|
| Number | 7 | 8 | 8 | 8 | 8 |
| BW (g) | 610 ± 12 | 793 ± 17 a | 606 ± 19 | 588 ± 26 b | 644 ± 22 |
| Left kidney weight (g) | 2.36 ± 0.06 | 1.7 ± 0.06 a | 2.02 ± 0.04 | 1.77 ± 0.07 a | 1.5 ± 0.08 a,c |
| Left kidney weight/100 g BW | 0.39 ± 0.01 | 0.31 ± 0.01 a | 0.36 ± 0.01 | 0.31 ± 0.02 a | 0.29 ± 0.01 a,c |
| Systolic blood pressure (mm Hg) | 139 ± 1 | 164 ± 1 a | 143 ± 1 | 146 ± 1 b | 144 ± 1 c |
HFD, high-fat diet; AICAR/P, AICAR treatment during pregnancy; HFD + AICAR/L, high-fat diet plus AICAR treatment during lactation; HFD + AICAR/P, high-fat diet plus AICAR treatment during pregnancy. BW, body weight; n = 7–8/group; a p < 0.05 vs. control; b p < 0.05 HFD vs. HFD + AICAR/L; c p < 0.05 HFD vs. HFD + AICAR/P.