Table 3.

Plasma l-citrulline, l-arginine, ADMA, and SDMA levels in 16-week-old male offspring exposed to high-fat diet (HFD) and AICAR in pregnancy or lactation.

Groups	Control	HFD	AICAR/P	HFD + AICAR/L	HFD + AICAR/P
L-citrulline	59.7 ± 4.5	53.7 ± 3.4	55.1 ± 4.6	57.1 ± 3.1	62.7 ± 3
L-arginine	141.4 ± 6.2	104.6 ± 4.4 a	171.2 ± 10.6 a	115.5 ± 3.3 a	140.2 ± 7.2 c
ADMA	1.35 ± 0.12	1.42 ± 0.09	1.73 ± 0.11 a	1.53 ± 0.06	1.19 ± 0.07
SDMA	0.57 ± 0.11	0.7 ± 0.03	0.7 ± 0.06	0.52 ± 0.02 b	0.49 ± 0.05 c
L-arginine-to-ADMA ratio	110 ± 12	75 ± 3 a	99 ± 3	76 ± 3 a	118 ± 4 c

ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; HFD, high-fat diet; AICAR/P, AICAR treatment during pregnancy; HFD + AICAR/L, high-fat diet plus AICAR treatment during lactation; HFD + AICAR/P, high-fat diet plus AICAR treatment during pregnancy; n = 7/group; ^a p < 0.05 vs. control; ^b p < 0.05 HFD vs. HFD + AICAR/L; ^c p < 0.05 HFD vs. HFD + AICAR/P.