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. 2020 Feb 20;12(2):544. doi: 10.3390/nu12020544

Figure 5.

Figure 5

Histology of colonic tissues during the course of disease development. Representative images depicting H&E staining of colon tissues in mice fed AIN or TWD diets obtained prior to DSS treatment (A–C), during active colitis (D–F), during recovery from gut injury (G–I) and at the study end (J–L). Descriptions of tissue histology and image magnification: (A) normal colon (200×); (B) normal colon with occasional mild multifocal lymphocytic inflammation (white arrow) and gut-associated lymphoid tissue (black arrow) (200×); (C) normal colon (200×); (D) neutrophilic and lymphoplasmacytic colitis with inflammation in the mucosa and submucosa (white arrow) (400×); (E,F) neutrophilic and lymphoplasmacytic colitis with inflammation of the mucosa and submucosa (white arrow), mucosal ulceration (orange arrow), and loss of glands (E, 200×; F, 400×); (G) colon with mild lymphoplasmacytic and neutrophilic mucosal inflammation (200×); (H,I) Gastrointestinal intraepithelial neoplasia (blue arrow) (H, 100x; I, 400×); (J) normal colonic mucosa (200×); (K) colon adenoma (A) at low magnification (40×); and (L) colon adenoma (Ad) at high magnification (400×). Scale bar = 100 μm.