Table 4.
GSH, GSH-related enzyme activities, lipid peroxidation, and inflammation in mice liver a.
| Control | HFHC | HFHC + 0.05% deAND | HFHC + 0.1% deAND | |
|---|---|---|---|---|
| GSH (nmol/mg protein) | 2.81 ± 0.99 | 0.26 ± 0.03 * | 0.24 ± 0.05 | 0.32 ± 0.04 # |
| TBARS (nmol MDA/mg protein) | 0.79 ± 0.14 | 0.73 ± 0.14 | 0.76 ± 0.22 | 0.81 ± 0.14 |
| GSH peroxidase (nmol/min/mg protein) |
330.7 ± 62.0 | 283.3 ± 24.2 | 268.3 ± 72.3 | 243.2 ± 43.1 |
| GSH reductase (nmol/min/mg protein) |
49.6 ± 3.5 | 43.6 ± 2.9 * | 48.1 ± 5.8 | 50.6 ± 5.3 # |
| GSH-S-transferase (nmol/min/mg protein) |
317.7 ± 64.6 | 370.0 ± 39.9 | 297.2 ± 57.9 | 373.9 ± 86.7 |
| TNF-α (pg/mg protein) | 38.1 ± 7.5 | 67.7 ± 15.5 * | 54.4 ± 6.0 | 43.6 ± 12.0 # |
| IL-1β (pg/mg protein) | 0.04 ± 0.01 | 0.09 ± 0.06 * | 0.06 ± 0.01 | 0.05 ± 0.02 |
a Values are the mean ± SD, n = 6. Mice were fed the different experimental diets for seven weeks. * Significantly different from Control group, p < 0.05. # Significantly different from HFHC group, p < 0.05. Abbreviations: GSH, Glutathione; TBARS, thiobarbituric acid–reactive substance; MDA, malondialdehyde; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-alpha.