Table 5.

Assessment of risk of bias for the preclinical animal studies using CYRCL’s tool.

Studies	Selection Bias			Performance Bias		Detection Bias		Attrition Bias	Reporting Bias	Others
	Random Sequence Generation	Baseline Characteristics	Allocation Concealment	Random Housing	Blinding	Random Outcome Assessment	Blinding	Incomplete Outcome Data	Selective Outcome Reporting	Other sources of Bias
[31]	No	Yes	U	No	No	Yes	No	Yes	Yes	Yes
[30]	No	Yes	U	No	No	No	No	Yes	Yes	U
[32]	Yes	Yes	U	No	No	Yes	No	No	Yes	U
[33]	Yes	Yes	U	No	No	No	No	Yes	Yes	U
[34]	Yes	Yes	U	No	No	No	No	Yes	Yes	U
[35]	Yes	Yes	U	No	No	Yes	No	No	Yes	Yes
[36]	Yes	Yes	U	Yes	No	No	No	No	yes	U
[37]	Yes	Yes	U	No	No	No	Yes	No	Yes	U
[38]	Yes	Yes	U	No	No	Yes	No	Yes	Yes	U
[39]	Yes	Yes	U	No	No	Yes	No	No	Yes	U

“Yes” to indicate a low risk of bias, “No” to indicate a high risk of bias or “U” to indicate an uncertain level of bias.