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. 2020 Jan 30;10(2):72. doi: 10.3390/brainsci10020072

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CA1 pyramidal neurons from diabetic mice were hyperexcitable. (A) Percent of CA1 pyramidal neurons firing any action potentials within the 10 min recording period while being perfused with either ACSF or ACSF containing 100 µM 4-aminopyridine (4-AP). (B) Action potential firing frequency (Hz) of CA1 pyramidal neurons during the 10 min recording period while being perfused with either ACSF or ACSF containing 100 µM 4-AP. Data were obtained from 9-11 cells of 8 db/+ control and 13 cells from 5 db/db diabetic mice. Asterisk (*) indicates significant difference from the corresponding non-diabetic control whereas the boxed circle () indicates significant difference after application of 4-AP from the same non-diabetic or diabetic ACSF group (p < 0.05; Jonckheere–Terpstra k independent groups test).

Inline graphic — CA1 pyramidal neurons from diabetic mice were hyperexcitable. (A) Percent of CA1 pyramidal neurons firing any action potentials within the 10 min recording period while being perfused with either ACSF or ACSF containing 100 µM 4-aminopyridine (4-AP). (B) Action potential firing frequency (Hz) of CA1 pyramidal neurons during the 10 min recording period while being perfused with either ACSF or ACSF containing 100 µM 4-AP. Data were obtained from 9-11 cells of 8 db/+ control and 13 cells from 5 db/db diabetic mice. Asterisk (*) indicates significant difference from the corresponding non-diabetic control whereas the boxed circle () indicates significant difference after application of 4-AP from the same non-diabetic or diabetic ACSF group (p < 0.05; Jonckheere–Terpstra k independent groups test).