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. 2020 Jan 30;10(2):72. doi: 10.3390/brainsci10020072

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CA1 pyramidal neurons from diabetic mice displayed more excitatory post-synaptic currents. Excitatory post-synaptic currents (EPSC) event frequency of small EPSCs (≤20 pA) or large EPSCs (>20 pA) recorded for one minute every 5 min of recording in CA1 pyramidal neurons from control or diabetic mice. (A) Small EPSC frequency (Hz) recorded in CA1 pyramidal neurons from control (open bars) or diabetic (filled blue bars) mice before and after application of 4-AP. Asterisk (*) indicates significant difference from the corresponding non-diabetic control whereas boxed circle () indicates significant difference after application of 4-AP from the same non-diabetic or diabetic ACSF group (p < 0.05; Jonckheere–Terpstra k independent groups test). (B) Large EPSC frequency (Hz) recorded in CA1 pyramidal neurons from control (open bars) or diabetic (filled blue bars) mice. Data were obtained from 11 cells from 8 db/+ control and 12 cells from 5 db/db diabetic mice. The large EPSCs recorded from CA1 pyramidal neurons were significantly greater after 4-AP in both control and diabetic mice although there was no difference in the frequency between control and diabetic mice at any time point examined either before or after 4-AP.

Inline graphic — CA1 pyramidal neurons from diabetic mice displayed more excitatory post-synaptic currents. Excitatory post-synaptic currents (EPSC) event frequency of small EPSCs (≤20 pA) or large EPSCs (>20 pA) recorded for one minute every 5 min of recording in CA1 pyramidal neurons from control or diabetic mice. (A) Small EPSC frequency (Hz) recorded in CA1 pyramidal neurons from control (open bars) or diabetic (filled blue bars) mice before and after application of 4-AP. Asterisk (*) indicates significant difference from the corresponding non-diabetic control whereas boxed circle () indicates significant difference after application of 4-AP from the same non-diabetic or diabetic ACSF group (p < 0.05; Jonckheere–Terpstra k independent groups test). (B) Large EPSC frequency (Hz) recorded in CA1 pyramidal neurons from control (open bars) or diabetic (filled blue bars) mice. Data were obtained from 11 cells from 8 db/+ control and 12 cells from 5 db/db diabetic mice. The large EPSCs recorded from CA1 pyramidal neurons were significantly greater after 4-AP in both control and diabetic mice although there was no difference in the frequency between control and diabetic mice at any time point examined either before or after 4-AP.