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. 2020 Mar 13;8:33. doi: 10.1186/s40478-020-00900-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Images from a 100 μm-thick brain section with a superficial cavitated microinfarct in the motor cortex (case 1). The section was first scanned with 11.7 T MRI (a-d) and then double-labeled for Coll4 and UEA-l (e) after capturing autofluorescence (f). a The cavity of the microinfarct gave a hyperintense signal in the T2-weighted image. b The T1-weighted MRI signal was hypointense in the microinfarct cavity and in tissue areas that showed thinning. c The PD-weighted image exhibited a hypointense signal in the core and a slightly hyperintense signal in the rim of the microinfarct cavity. d In the T2*-weighted image, large vessels and the microbleed in the cavity produced magnified hypointense signals (blooming effect). e The microinfarct cavity contained damaged microvessels and the rim of the cavity was rich in Coll4-positive string vessels that lacked UEA-l staining. f Autofluorescence (AF) of the tissue was reduced in the microinfarct cavity and in areas with tissue thinning around the cavity. Betz cells could also be identified based on their autofluorescence (arrow in inset d₁). Scale bars: 500 μm (e-f)