Table 2.
Baseline predictors of change in NPI total and NPI carer distress total using mixed-effects modelling.
| PD | Control | |||||||
|---|---|---|---|---|---|---|---|---|
| β | SE | t-value | p-value | β | SE | t-value | p-value | |
| NPI total | ||||||||
| Basic model | ||||||||
| Sex (Male) | 1.2 | 1.3 | 1.0 | 0.329 | −0.8 | 1.0 | −0.847 | 0.399 |
| Age | −0.1 | 0.1 | −1.6 | 0.105 | 0.1 | 0.1 | 0.940 | 0.350 |
| Time | 0.4 | 0.4 | 0.9 | 0.390 | 0.6 | 0.5 | 1.193 | 0.235 |
| Basic model + MDS-UPDRS III | ||||||||
| MDS-UPDRS III | 0.0 | 0.1 | 0.6 | 0.563 | ||||
| MDS-UPDRS III × Time | 0.1 | 0.0 | 2.0 | 0.044 | ||||
| Basic model + MoCA | ||||||||
| MoCA | −0.4 | 0.2 | −1.8 | 0.075 | 0.0 | 147.6 | 0.1 | 0.900 |
| MoCA × Time | −0.1 | 0.1 | −0.7 | 0.457 | −0.5 | 126.3 | −1.9 | 0.057 |
| NPI carer distress total | ||||||||
| Basic model | ||||||||
| Sex (Male) | 0.8 | 0.6 | 1.3 | 0.206 | 0.1 | 0.5 | 0.124 | 0.901 |
| Age | 0.0 | 0.0 | −0.3 | 0.791 | 0.0 | 0.0 | 0.525 | 0.601 |
| Time | 0.3 | 0.3 | 1.0 | 0.404 | 0.3 | 0.3 | 1.119 | 0.265 |
| Basic model + MDS-UPDRS III | ||||||||
| MDS-UPDRS III | 0.0 | 0.0 | 0.1 | 0.957 | ||||
| MDS-UPDRS III × Time | 0.1 | 0.0 | 3.1 | 0.002 | ||||
| Basic model + MoCA | ||||||||
| MoCA | −0.3 | 0.1 | −2.7 | 0.007 | 0.0 | 147.8 | −0.2 | 0.865 |
| MoCA × Time | 0.0 | 0.1 | −0.8 | 0.432 | −0.2 | 127.2 | −1.9 | 0.065 |
Basic model includes age, sex and time as covariates. Figures highlighted in bold indicate significant results after Benjamini–Hochberg procedure. Abbreviations: MoCA = Montreal Cognitive Assessment, MDS-UPDRS III = Movement Disorder Society Unified Parkinson’s Disease Rating Scale part III.