Table 3.
Predictors of change in quality of life (PDQ-39) using mixed-effects modelling.
| Basic Model | β | SE | t Value | p-Value |
|---|---|---|---|---|
| Basic model | ||||
| Sex (Female) | −3.4 | 1.7 | −2.1 | 0.041 |
| Education (Years) | −0.6 | 0.2 | −2.5 | 0.012 |
| Age | −0.3 | 0.1 | −3.9 | <0.001 |
| LEDD | 0.0 | 0.0 | 3.1 | 0.002 |
| MDS-UPDRS III | 0.4 | 0.0 | 8.3 | <0.001 |
| Time (Assessment) | 12.5 | 3.4 | 3.7 | <0.001 |
| MoCA | −0.1 | 0.2 | −0.4 | 0.654 |
| MoCA × Time | −0.5 | 0.1 | −3.8 | <0.001 |
| Basic model + NPI Total | ||||
| NPI Total | 0.3 | 0.1 | 3.9 | <0.001 |
| NPI Total × Time | 0.0 | 0.1 | 0.6 | 0.551 |
Basic model includes age, sex, years of education, MoCA, LEDD, MDS-UPDRS Part III, MoCA over time as covariates. Figures highlighted in bold indicate significant results after Benjamini–Hochberg procedure. Abbreviations: PDQ-39 = Parkinson’s Disease Questionnaire, MoCA = Montreal Cognitive Assessment, LEDD = levodopa equivalent daily dose, MDS-UPDRS III = Movement Disorder Society Unified Parkinson’s Disease Rating Scale part III, NPI = Neuropsychiatric Inventory.