Table 2.
Post hoc models
| Covariates | Model 1 (Fig. 2) | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 |
|---|---|---|---|---|---|---|
| Age | X | X | X | X | X | X |
| Sex | X | X | X | X | X | X |
| ApoE ε4 allele (number) | X | X | X | X | X | X |
| Years of education | X | |||||
| Baseline MMSE | X | X | X | X | X | |
| Baseline EF | X | X | X | X | X | X |
| Baseline brain parenchymal volume (cross-sectional) | X | X | X | X | X | |
| Baseline white matter hyperintensity volume | X | X | X | X | X | X |
| Baseline hippocampal volume (cross-sectional) | X | |||||
| Acetylcholinesterase inhibitor use | X | X | X | X | X | X |
| Memantine use | X | X | X | X | X | X |
| Anti-inflammatory (corticosteroid, NSAID, and ASA 81 mg) | X | X | X | |||
| Corticosteroid use | X | |||||
| NSAID use | X | |||||
| ASA 81 mg use | X | |||||
| Markers included in model | NGAL, MPO, IL-8, MIP-1β, TNF | NGAL, MPO, IL-8, MIP-1β, TNF | NGAL, MPO, IL-8, MIP-1β, TNF | NGAL, MPO, IL-8, MIP-1β, TNF | NGAL, MPO, IL-8, MIP-1β, TNF | NGAL, MPO, IL-8, MIP-1β |
| Model fit indices | X2p value 0.6402, RMSEA 0.000, RMSEA p value 0.947, CFI 1.000, TLI 1.033, SRMR 0.078 | X2p value 0.5295, RMSEA 0.000, RMSEA p value 0.854, CFI 1.000, TLI 1.012 SRMR 0.084 | X2p value 0.5819, RMSEA 0.000, RMSEA p value 0.930, CFI 1.000, TLI 1.012, SRMR 0.078 | X2p value 0.5088, RMSEA 0.000, RMSEA p value 0.904, CFI 1.000, TLI 1.006, SRMR 0.079 | X2p value 0.6964, RMSEA 0.000, RMSEA p value 0.961, CFI 1.000, TLI 1.045, SRMR 0.079 | X2p value 0.6774, RMSEA 0.000, RMSEA p value 0.940, CFI 1.000, TLI 1.042, SRMR 0.073 |
| Sample size | 109 | 81 | 109 | 109 | 109 | 109 |
| Effect of baseline neutrophil factor on follow-up executive function (standardized β [95% confidence interval], p value) | β = − 0.152 [− 0.274, − 0.029], p = 0.015 | β = − 0.146 [− 0.288, − 0.003], p = 0.045 | β = − 0.134 [− 0.273, − 0.011], p = 0.033 | β = − 0.131 [− 0.252, − 0.009], p = 0.036 | β = − 0.138 [− 0.252, − 0.009], p = 0.026 | β = − 0.137 [− 0.267, − 0.007], p = 0.039 |