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. 2020 Mar 14;13:19. doi: 10.1186/s13045-020-00858-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — (1) Tumor microenvironment and VM: TAFs (tumor-associated fibroblasts) promote VM formation through secreting TGF-β and SDF-1, and TAMs (tumor-associated macrophages) promote VM formation by amplifying IL-6and TGF-β secretion. (2) The process of EMT participating in the VM formation: epithelial cells are transformed into mesenchymal phenotype cells by specific procedures, including reduction of expression of cell adhesion molecules (such as E-cadherin) and some upregulated proteins (such as VE-cadherin-biomarker of VM).