Table 1.

MiRNAs in VM

MiRNA	Cancer type	Target	Function characteristic	Effect of VM formation	Reference
miRNA-27b	Ovarian cancer	VE-cadherin	inhibits ovarian cancer cell migration and VM via binding to the 3′-untranslated region(3′UTR) of VE-cadherin mRNA	Suppress	[98]
miRNA-584-3P	Glioma	ROCK1	Disturbs hypoxia-induced ROCK1-dependent stress fiber formation	Suppress	[87]
MiRNA-let-7f	Glioma	POSTN	Disturbs the POSTN-dependent migration	Suppress	[86]
miR141	Glioma	EphA2	Inhibits EphA2 expression	Suppress	[88]
miR-27a-3p	Hepatocellular carcinoma	VE-cadherin	Targets the 3′-UTR of VE-cadherin, and suppresses EMT signaling	Suppress	[92]
miR-193b	Breast cancer	DDAH1	Regulates MDA-MB-231 cells migration and VM formation via targeting DDAH1	Suppress	[97]
miR-125a/let-7e	Breast cancer	IL-6, IL-6R, STAT3	Suppresses IL-6-induced adhesion of monocytes to ECs and VM formation	Suppress	[96]
miR-200a	Ovarian cancer	EphA2	Inhibits EphA2 expression	Suppress	[99]
miR-490-3p	Clear cell renal cell carcinoma	Vimentin	-	Suppress	[28]
miR-745	Ovarian cancer	VEGFR/AKT1/SRC-α	Decreases the levels of VEGFA, AKT1, and SRC-α transducers and exerts a negative regulation of VEGFA by specific binding to its 3'UTR	Suppress	[74]
miR-9	Glioma	Stathmin (STMN1)	targets the 3′-UTR of STMN1	Suppress	[75]
miR-186	Prostate cancer	Twist1	-	Suppress	[84]
miR-101	Hepatocellular carcinoma	TGF-β1, Smad2	Targets TGF-ΒR1 and Smad2 to attenuate TGF-β signaling transduction in tumor cells and blocks SDF1 signaling	Suppress	[93]
miR-124	Cervical cancer	Amotl1	Represses VM, migration, and invasion in HeLa and C33A cells by regulating AmotL1’s 3'untranslated region (3'UTR)	Suppress	[85]