Western blot analysis of lysates of human platelets stimulated with thrombin (0.1U/mL) for the indicated time. (A) Images of representative immunoblots of phosphorylation of ASK1, MKK3, MKK4, MKK6, MKK7 and p38 using phospho-specific antibodies. Phospho-blots were reprobed for their respective total (anti-ASK1, anti-MKKs, anti-p38) antibodies to ensure equal protein loading. (B) Quantification of band intensities of each MKKs from (A).