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. 2020 Mar 13;11:116. doi: 10.1186/s13287-020-01624-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Freshly harvested or cryopreserved CD362⁺ UC-hMSCs have comparable therapeutic effects in E. coli-induced lung injury. Freshly harvested from culture or thawed from cryostorage and immediately administered, CD362⁺ UC-hMSCs ameliorated E. coli ARDS-induced decrement in arterial oxygenation (a). There were no significant changes in lung tissue wet to dry ratio (b). Freshly harvested CD362⁺ UC-hMSCs alone significantly reversed the decrease in lung static compliance (c). Both fresh and cryopreserved CD362⁺ UC-hMSCs reduced lung E. coli bacterial load (d), total BAL infiltrating leukocytes (e) BAL neutrophils (f), BAL IL-1β (g), and BAL IL-6 (i), and had a trending but not significant effect on CINC-1 (h) in this series. Abbreviations: vehicle, treatment with vehicle alone; UC 362⁺ fresh, umbilical cord-derived CD362⁺ hMSC freshly harvested from culture; UC 362⁺ cryo, umbilical cord-derived CD362⁺ hMSC thawed from cryostorage and immediately administered; BAL, bronchoalveolar lavage; IL-1β, interleukin 1 beta; CINC-1, cytokine-induced neutrophil chemoattractant 1; IL-6, interleukin 6. Error bars represent standard deviation. *Significantly (P < 0.05) different from vehicle control group