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. 2020 Mar 13;11:116. doi: 10.1186/s13287-020-01624-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CD362⁺ UC-hMSCs lose function after passage 3 in E. coli pneumonia. Passage 3 CD362⁺ UC-hMSCs ameliorated the E. coli-induced decrement in arterial oxygenation (a), the increase in wet to dry ratio (b), the decrease in static lung compliance (c) and BAL bacterial load (d) compared to vehicle control. These effects were not observed at any later hMSC passage. All CD362⁺ UC-hMSC passages reduced the total infiltrating leukocyte (e) and neutrophil count (f) in BAL compared to the vehicle control. There was no effect of CD362⁺ UC-hMSCs on BAL IL-1β concentration (h) compared to the vehicle control. Passage 3 CD362⁺ UC-hMSCs ameliorated the E. coli-induced increase in BAL CINC-1 concentration (i) compared to the vehicle control, while passages 3 to 7 decreased IL-6 concentration (j). Abbreviations: vehicle, treatment with vehicle alone; passage, passage number of umbilical cord-derived CD362⁺ hMSC, BAL, bronchoalveolar lavage; IL-1β, interleukin 1 beta; CINC-1, cytokine-induced neutrophil chemoattractant 1; IL-6, interleukin 6. Error bars represent standard deviation. *Significantly (P < 0.05) different from the vehicle control group