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. 2020 Mar 14;21:20. doi: 10.1186/s12910-020-0463-x

Table 1.

Overview of results

Real-world “House, M.D.” Comparison of real-world versus “House, M.D.” *
All diseases (n) 30,000 181
Orphan diseases overall (n) 7000 42
Ratio of orphan diseases among all diseases 23% 23.2% p = 0.96
Orphan diseases with orphan drug approval 534 15
Ratio of orphan diseases with orphan drug approval among all orphan diseases 7.6% 39.4% p = 0.0192

*p-value from chi-squared test with Yate’s correction