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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Pathol. 2019 Nov 28;250(2):231–242. doi: 10.1002/path.5363

Figure 1. The PI3K pathway is activated in Pbsn-cre4Prb/+;PI3KGOF/+ prostates.

Figure 1.

(A) Dorsal prostate sections from 4, 7 and 12 month old Pbsn-cre4Prb+/+;PI3KGOF/+ (control) and Pbsn-cre4Prb/+;PI3KGOF/+ male mice were stained with an antibody recognizing the phosphorylated form of p70 S6 kinase. (B) There is a greater frequency of phospho-p70 S6 kinase immunopositive epithelial cells in Pbsn-cre4Prb/+;PI3KGOF/+ mice than in controls at 4, 7, and 12 months of age, and a greater frequency of phospho-p70 S6 kinase immunopositive stromal cells in Pbsn-cre4Prb/+;PI3KGOF/+ mice than in controls at 7 and 12 months of age Results are mean ± SE of 2–4 mice. Significant differences among groups: * = p ≤ 0.05; ** = p ≤ 0.01; *** = p ≤ 0.001. Scale bar = 50 μm.